HHMMiR is a de novo approach that is used for miRNA hairpin prediction in the absence of evolutionary conservation. This…
PDBeMotif is a highly fast and powerful search tool that facilitates exploration of the Protein Data Bank (PDB) by combining…
In compact globular proteins, a polypeptide often makes a sharp turn called a reverse turn. For example, these turns often link…
According to one definition a turn is a structural motif where the Cα atoms of two residues separated by a few…
Secondary structure elements are elementary structural patterns that are present in most, if they are not all, known proteins. These are…
The structure–activity relationship (SAR) is the relationship between the chemical structure of a molecule and its biological activity. This idea was first presented by Crum-Brown…
Protein structure comparisons are also basic parts of methods for their structure prediction and prediction of function from their structure. Structure comparison methods have mostly three main components: …
The structure of proteins related by evolution is remarkably alike even when the observed sequence similarities are statistically marginal or…
Steps of Homology Modeling Template Selection The first step in protein structural modeling is to select appropriate structural templates. The…
The alpha carbon (Cα) in the center of each amino acid is held in the main chain by two rotatable…