DAVID (the database for annotation, visualization and integrated discovery) is a free online bioinformatics resource developed by the Laboratory of Immunopathogenesis and Bioinformatics (LIB). All tools in the DAVID Bioinformatics Resources aim to provide functional interpretation of large lists of genes derived from genomic studies, e.g. microarray and proteomics studies.
The DAVID Bioinformatics Resources consists of the DAVID Knowledgebase and five integrated, web-based functional annotation tool suites: the DAVID Gene Functional Classification Tool, the DAVID Functional Annotation Tool, the DAVID Gene ID Conversion Tool, the DAVID Gene Name Viewer and the DAVID NIAID Pathogen Genome Browser. The expanded DAVID Knowledgebase now integrates almost all major and well-known public bioinformatics resources centralized by the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of diverse gene/protein identifiers and annotation terms from a variety of public bioinformatics databases. For any uploaded gene list, the DAVID Resources now provides not only the typical gene-term enrichment analysis, but also new tools and functions that allow users to condense large gene lists into gene functional groups, convert between gene/protein identifiers, visualize many-genes-to-many-terms relationships, cluster redundant and heterogeneous terms into groups, search for interesting and related genes or terms, dynamically view genes from their lists on bio-pathways and more.
DAVID now provides a comprehensive set of functional annotation tools for investigators to understand the biological meaning behind a large list of genes.
- Identify enriched biological themes, particularly GO terms
- Discover enriched functional-related gene group
- Cluster redundant annotation terms
- Visualize genes on BioCarta & KEGG pathway maps
- Display related many-genes-to-many-terms on 2-D view
- Search for other functionally related genes not in the list
- List interacting proteins
- Explore gene names in batch
- Link gene-disease associations
- Highlight protein functional domains and motifs
- Redirect to related literatures
- Convert gene identifiers from one type to another.
DAVID is composed of four main modules: Annotation Tool, GoCharts, KeggCharts, and DomainCharts. The Annotation Tool is an automated method for the functional annotation of gene lists. Any combination of annotation data can be chosen from 10 options by selecting the appropriate checkboxes. The annotations are added to the submitted gene list by selecting the upload button, which returns an HTML table containing the user’s original list of identifiers appended with the chosen functional annotations. Unannotated genes are included in the output with no appended data for tracking purposes.
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We are providing “DAVID Analysis” service to the bioinformatics community through our expertise for investigators to explore and view functionally related genes together, as a unit, to concentrate on the larger biological network rather than at the level of an individual gene.